Sagaia (Mega Drive)
Saint Sword (Mega Drive)
Samurai Shodown (Mega Drive)
Saturday Night Slam Masters (Mega Drive)
Scooby-Doo Mystery (Mega Drive)
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Second Samurai (Mega Drive)
Sensibe Soccer (Mega Drive)
Sensible Soccer: European Champions: 92/93 Edition (Mega Drive)
Shadow Dancer: The Secret of Shinobi (Mega Drive)
Shadow of the Beast (Mega Drive)
Shadow of the Beast II (Mega Drive)
Shadowrun (Mega Drive)
Shanghai II: Dragon's Eye (Mega Drive)
Shaq Fu (Mega Drive)
Shining Force (Mega Drive)
Shining Force 2 (Mega Drive)
Shining in the Darkness (Mega Drive)
Shinobi III : Return of the Ninja Master (Mega Drive)
Shuihuzhuan (Mega Drive)
Side Pocket (Mega Drive)
Sink or Swim (Mega Drive)
Skeleton Krew (Mega Drive)
Skitchin' (Mega Drive)
Slap Fight (Mega Drive)
Smash TV (Mega Drive)
Snow Bros. Nick & Tom (Mega Drive)
Sonic & Knuckles (Mega Drive)
Sonic 3D Blast (Mega Drive)
Sonic Classics (Mega Drive)
Sonic Spinball (Mega Drive)
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Sonic the Hedgehog 2 (Mega Drive)
Sonic the Hedgehog 3 (Mega Drive)
Sorcerer's Kingdom (Mega Drive)
Sorcerian (Mega Drive)
Space Harrier II (Mega Drive)
Sparkster (Mega Drive)
Speedball 2: Brutal Deluxe (Mega Drive)
Spider-Man & Venom: Maximum Carnage (Mega Drive)
Spider-Man & Venom: Separation Anxiety (Mega Drive)
Spider-Man and the X-Men: Arcade's Revenge (Mega Drive)
Spiritual Warfare (Mega Drive)
Spirou (Mega Drive)
Splatterhouse 2 (Mega Drive)
Splatterhouse 3 (Mega Drive)
Sports Talk Baseball (Mega Drive)
Spot Goes to Hollywood (Mega Drive)
Star Control (Mega Drive)
Star Trek: Deep Space Nine: Crossroads of Time (Mega Drive)
Starflight (Mega Drive)
Stargate (Mega Drive)
Steel Talons (Mega Drive)
Stormlord (Mega Drive)
Street Fighter II Special Champion Edition (Mega Drive)
Street Racer (Mega Drive)
Streets of Rage (Mega Drive)
Streets of Rage 2 (Mega Drive)
Streets of Rage 3 (Mega Drive)
Strider (Mega Drive)
Strider 2 (Mega Drive)
Striker (Mega Drive)
Sub-Terrania (Mega Drive)
Sunset Riders (Mega Drive)
Super Baseball 2020 (Mega Drive)
Super Fantasy Zone (Mega Drive)
Super Hang-On (Mega Drive)
Super Hydlide (Mega Drive)
Super Kick Off (Mega Drive)
Super Monaco GP (Mega Drive)
Super Real Basketball (Mega Drive)
Super Skidmarks (Mega Drive)
Super Street Fighter II (Mega Drive)
Super Thunder Blade (Mega Drive)
Surging Aura (Mega Drive)
Sword of Sodan (Mega Drive)
Sword of Vermilion (Mega Drive)
Sylvester and Tweety in Cagey Capers (Mega Drive)
Syndicate (Mega Drive)